Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01IGU
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| Former ID |
DIB018863
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| Drug Name |
APA
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| Synonyms |
1-Aminooxy-3-aminopropane; 3-aminooxy-1-aminopropane; O-(3-aminopropyl)hydroxylamine; 98532-00-4; CHEMBL281021; 1-Propanamine, 3-(aminooxy)-; 3-Aminooxy-1-propanamine; XAP; 3-Aminooxypropylamine; 3-(aminooxy)propan-1-amine; GTPL5139; AC1L22F5; CTK3I7322; DTXSID20243634; BDBM50005719; AKOS006348478; (APA)O-(3-Amino-propyl)-hydroxylamine; O-(3-Aminopropyl)hydroxylamine,; 1-aminooxy-3-aminopropane
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C3H10N2O
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| Canonical SMILES |
C(CN)CON
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| InChI |
1S/C3H10N2O/c4-2-1-3-6-5/h1-5H2
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| InChIKey |
VSZFWDPIWSPZON-UHFFFAOYSA-N
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| CAS Number |
CAS 98532-00-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ornithine decarboxylase (ODC1) | Target Info | Inhibitor | [2], [3] |
| BioCyc | Putrescine biosynthesis I | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Ornithine degradation | |||
| CCKR signaling map ST | ||||
| Pathwhiz Pathway | Spermidine and Spermine Biosynthesis | |||
| Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5139). | |||
| REF 2 | Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion. Antimicrob Agents Chemother. 2007 Feb;51(2):528-34. | |||
| REF 3 | 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44. | |||
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