Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01WLC
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| Former ID |
DAP000749
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| Drug Name |
Metolazone
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| Synonyms |
Diulo; Metalazone; Metalozone; Metenix; Metolazona; Metolazonum; Microx; Mykrox; Oldren; Xuret; Zaroxolyn; Metolazona [INN-Spanish]; Metolazonum [INN-Latin]; Mykrox (TN); SR 720-22; Zaroxolyn (TN); SR-720-22; Metolazone (JAN/USP/INN); Metolazone [USAN:BAN:INN:JAN]; Mykrox, Zaroxolyn, Diulo, Metolazone; 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Edema [ICD-11: MG29; ICD-10: R60] | Approved | [1], [2], [3] | |
| Hypertension [ICD-11: BA00-BA04] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C16H16ClN3O3S
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| Canonical SMILES |
CC1NC2=CC(=C(C=C2C(=O)N1C3=CC=CC=C3C)S(=O)(=O)N)Cl
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| InChI |
1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
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| InChIKey |
AQCHWTWZEMGIFD-UHFFFAOYSA-N
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| CAS Number |
CAS 17560-51-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4904668, 7847497, 7979975, 8150176, 8152610, 10321392, 11335450, 11360689, 11363350, 11365912, 11368474, 11374036, 11376636, 11461661, 11466140, 11467260, 11485578, 11485799, 11489557, 11492044, 11494270, 14926227, 24724532, 26613200, 26680432, 26747536, 26747537, 26753589, 26753590, 29223276, 46509058, 47365083, 47365084, 47588891, 47736365, 47736366, 47885305, 48259128, 49698717, 50041173, 50106417, 50106418, 50267110, 56413187, 56463247, 56463561, 57322175, 85087884, 85787877, 90341106
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| ChEBI ID |
CHEBI:64354
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| ADReCS Drug ID | BADD_D01444 | |||
| SuperDrug ATC ID |
C03BA08
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| SuperDrug CAS ID |
cas=017560519
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Solute carrier family 12 member 3 (SLC12A3) | Target Info | Blocker | [4] |
| Pathwhiz Pathway | Kidney Function | |||
| Reactome | Cation-coupled Chloride cotransporters | |||
| WikiPathways | Transport of inorganic cations/anions and amino acids/oligopeptides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4838). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075543. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest. 2001 Jul;108(2):215-22. | |||
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