Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02JIS
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| Former ID |
DNAP001705
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| Drug Name |
Iobenguane I-123
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| Synonyms |
Iobenguane (123I); UNII-P2TH1XYZ84; m-Iodobenzylguanidine-123I; P2TH1XYZ84; Adreview; Iobenguane I 123; 123I-MIBG; 2-[(3-iodanylphenyl)methyl]guanidine; 76924-93-1; Iodine-123 metaiodobenzylguanidine; m-(123I)Iodobenzylguanidine; Iobenguane I 123 [USAN]; MyoMIBG-I 123 (TN); (123I)-m-Iodobenzylguanidine; AC1L367T; AC1Q50E3; CHEMBL1615777; SCHEMBL13158600; (123)I-MIBG; CHEBI:135134; 123 iodine metaiodobenzylguanidine; MOLI000966; 3-Iodobenzylguanidine (123I) (JAN); Guanidine, ((3-iodo(123I)phenyl)methyl)-; D01729
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| Drug Type |
Small molecular drug
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| Indication | Neuroendocrine cancer [ICD-11: 2B72.1; ICD-10: C7A] | Approved | [1] | |
| Company |
GE Healthcare
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H10IN3
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| Canonical SMILES |
C1=CC(=CC(=C1)I)CN=C(N)N
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| InChI |
1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9-4
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| InChIKey |
PDWUPXJEEYOOTR-IUAIQHPESA-N
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| CAS Number |
CAS 76924-93-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7398973, 11111341, 11111342, 11466518, 11467638, 11486016, 14750688, 24278499, 43118198, 47349354, 47573370, 47646555, 47720604, 48169363, 49698519, 50111105, 56219166, 57314158, 77939172, 85788868, 90341658, 99222771, 103113617, 103113618, 103215608, 104321834, 117356661, 117356662, 124749883, 124880479, 125820672, 127320057, 127320058, 127320059, 127320060, 127320061, 127320062, 127320063, 127320064, 127320065, 127320066, 128901924, 135114605, 137102707, 137138944, 142124139, 162916309, 175427085, 179225831, 179235742
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| ChEBI ID |
CHEBI:135134
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| ADReCS Drug ID | BADD_D01173 | |||
| SuperDrug ATC ID |
V09IX01
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Norepinephrine transporter (NET) | Target Info | Inhibitor | [2] |
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). | |||
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