Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02KIU
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| Former ID |
DAP000855
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| Drug Name |
Etonogestrel
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| Synonyms |
Etonogestrelum; Implanon; Implanon (TN); NuvaRing (TN); Etonogestrel (USAN/INN); (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one; 3-Ketodesogestrel; 3-Oxodesogestrel
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| Drug Type |
Small molecular drug
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| Indication | Contraception [ICD-11: QA21] | Approved | [1], [2] | |
| Therapeutic Class |
Contraceptive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C22H28O2
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| Canonical SMILES |
CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
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| InChI |
1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
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| InChIKey |
GCKFUYQCUCGESZ-BPIQYHPVSA-N
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| CAS Number |
CAS 54048-10-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12012881, 14752897, 14777213, 17194516, 43529146, 46505321, 47206056, 53789691, 56352980, 57371661, 74860218, 103565890, 114786833, 126686585, 135004061, 136314851, 137005554, 140504091, 144206191, 162262948, 164152391, 164826700, 175268832, 179150591, 193126307, 198993353, 210279789, 210282112, 223365925, 223673211, 226489730, 241094452, 249582869, 252349777
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| ChEBI ID |
CHEBI:50777
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| ADReCS Drug ID | BADD_D00852 | |||
| SuperDrug ATC ID |
G03AC08
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| SuperDrug CAS ID |
cas=054048101
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Binder | [3], [4] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7590). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7. | |||
| REF 4 | Endometrial effects of etonogestrel (Implanon) contraceptive implant. Curr Opin Obstet Gynecol. 2001 Jun;13(3):335-41. | |||
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