Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03BQJ
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| Former ID |
DNC010307
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| Drug Name |
2-p-tolyl-4H-chromen-4-one
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| Synonyms |
4'-Methylflavone; 2-(4-methylphenyl)-4H-chromen-4-one; 2-(4-methylphenyl)chromen-4-one; 2-p-Tolyl-chromen-4-one; CHEMBL16861; 2-p-tolyl-4H-chromen-4-one; 4'-Methylflavon; 4hlk; AC1LEMVU; Maybridge3_003060; Oprea1_528340; Oprea1_754899; 2-(p-tolyl)-chromen-4-one; SCHEMBL7593917; ZINC57876; MolPort-000-648-141; OPHKKQQCOYMLPW-UHFFFAOYSA-N; HMS1439L02; BDBM50310190; AKOS000603601; MCULE-3669298263; IDI1_014447; 41255-30-5; ST093690; BAS 01121718; NS-00120; 4H-1-Benzopyran-4-one, 2-(4-methylphenyl)-; AG-690/13115015
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H12O2
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| Canonical SMILES |
CC1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
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| InChI |
1S/C16H12O2/c1-11-6-8-12(9-7-11)16-10-14(17)13-4-2-3-5-15(13)18-16/h2-10H,1H3
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| InChIKey |
OPHKKQQCOYMLPW-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Monoamine oxidase type B (MAO-B) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of tryptophan utilization | |||
| Tryptophan degradation via tryptamine | ||||
| Dopamine degradation | ||||
| Putrescine degradation III | ||||
| Noradrenaline and adrenaline degradation | ||||
| KEGG Pathway | Glycine, serine and threonine metabolism | |||
| Arginine and proline metabolism | ||||
| Histidine metabolism | ||||
| Tyrosine metabolism | ||||
| Phenylalanine metabolism | ||||
| Tryptophan metabolism | ||||
| Drug metabolism - cytochrome P450 | ||||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| Dopaminergic synapse | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| 5-Hydroxytryptamine degredation | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| WikiPathways | Tryptophan metabolism | |||
| Dopamine metabolism | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. | |||
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