Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03DYT
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| Former ID |
DNC002400
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| Drug Name |
K252a
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| Synonyms |
K-252a, Nocardiopsis sp.; k-252a; ST50826373; (+)-K-252A; k-252a deriva-tives; AC1LAL9C; GTPL336; BDBM2580; CHEMBL416056; SCHEMBL13485248; HMS3229K08; ZINC3776578; 99533-80-9; CCG-206861; methyl hydroxy-methyl-oxo-[ ]carboxylate; B6828; methyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate; methyl (16S,18S,15R)-1
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C27H21N3O5
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| Canonical SMILES |
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
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| InChI |
1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
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| InChIKey |
KOZFSFOOLUUIGY-SOLYNIJKSA-N
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| CAS Number |
CAS 99533-80-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:43616
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein kinase D (PRKD1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | FSH Signaling Pathway | |||
| TGF_beta_Receptor Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| EGF receptor signaling pathway | ||||
| VEGF signaling pathway | ||||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | LPA receptor mediated events | |||
| IGF1 pathway | ||||
| Reactome | Sphingolipid de novo biosynthesis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 336). | |||
| REF 2 | Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. | |||
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