Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03LOG
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| Former ID |
DNC010899
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| Drug Name |
LINOLEIC ACID
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| Synonyms |
linoleic acid; 60-33-3; Linolic acid; Telfairic acid; (9Z,12Z)-octadeca-9,12-dienoic acid; cis,cis-Linoleic acid; Grape seed oil; Linoleate; cis,cis-9,12-Octadecadienoic acid; Emersol 315; cis-9,cis-12-Octadecadienoic acid; 9,12-Linoleic acid; Unifac 6550; 9Z,12Z-Linoleic acid; Extra Linoleic 90; 9-cis,12-cis-Linoleic acid; Polylin 515; Emersol 310; Polylin No. 515; Oils, grape; 9Z,12Z-octadecadienoic acid; alpha-Linoleic acid; all-cis-9,12-Octadecadienoic acid; Linoleic; acide linoleique; (Z,Z)-9,12-Octadecadienoic acid; acido lino
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H32O2
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| Canonical SMILES |
CCCCCC=CCC=CCCCCCCCC(=O)O
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| InChI |
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
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| InChIKey |
OYHQOLUKZRVURQ-HZJYTTRNSA-N
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| CAS Number |
CAS 60-33-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4750, 143213, 647847, 3139101, 7849987, 7887298, 8145523, 8616276, 10529224, 14897568, 17388946, 24882204, 24882205, 24896270, 24896275, 24896279, 24901678, 26752886, 26752887, 26752888, 26759057, 29196027, 29204334, 39289571, 47290906, 47662025, 48110221, 48416742, 48423611, 48425246, 49846046, 49854479, 50073971, 50105507, 50105508, 51004445, 53790748, 56312731, 57357741, 57651878, 85787692, 87572020, 87572080, 88831443, 92298594, 92309790, 99300704, 99302222, 103167732, 104046536
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| ChEBI ID |
CHEBI:17351
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Microbial Enzyme | Linoleate isomerase | |||
| Metabolic Reaction | Conjugation | |||
| Description | Linoleic acid can be metabolized by the linoleate isomerase of gut microbiota through conjugation. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid-binding protein 4 (FABP4) | Target Info | Inhibitor | [3] |
| KEGG Pathway | PPAR signaling pathway | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathway Interaction Database | AP-1 transcription factor network | |||
| Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |||
| Transcriptional regulation of white adipocyte differentiation | ||||
| WikiPathways | Lipid digestion, mobilization, and transport | |||
| Transcriptional Regulation of White Adipocyte Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1052). | |||
| REF 2 | Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions. Pharmacol Rev. 2019 Apr;71(2):198-224. | |||
| REF 3 | Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. | |||
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