Drug Information
Drug General Information | Top | |||
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Drug ID |
D03SSE
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Former ID |
DAP000790
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Drug Name |
Mechlorethamine
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Synonyms |
Antimit; Carolysine; Caryolysin; Caryolysine; Chlorethazine; Chlormethine; Cloramin; Clormetina; Dichloren; Embechine; Embichin; MBA; Mebichloramine; Mechlorethanamine; Mechloroethamine; Mecloretamina; Mustargen; Mustine; Mutagen; Nitrogranulogen; Thyldiethylamine; Dichlor amine; Me chloroethamine; Mecloretamina [Italian]; Mustine note; Nitrogen mustard; HN2; T 1024; TL 146; Chloramine (the nitrogen mustard); Chlormethine (INN); Chlormethine [INN:BAN]; Chlormethinum [INN-Latin]; Clormetina [INN-Spanish]; ENT-25294; HN-2; IBS-L0033631; Mustargen (TN); N-Lost; N-Methyl lost; Stickstofflost (ebewe); T-1024; Bis(2-chloroethyl)methylamine; Bis(beta-chloroethyl) methylamine; Bis(beta-chloroethyl)methylamine; Di(2-chloroethyl)methylamine; Methylbis(2-chloroethyl)amine; Methylbis(beta-chloroethyl)amine; Methyldi(2-chloroethyl)amine; N-Methyl-lost; N-Methyl-lost [German]; Nitrogen mustard (HN-2); Mitoxine (*Hydrochloride*); N,N-Di(chloroethyl)methylamine; N-Methyl-bis-chloraethylamin; N-Methyl-bis-chloraethylamin [German]; Nitol (*Hydrochloride*); Stickstofflost (*Hydrochloride*); N,N-Bis(2-chloroethyl)methylamine; N-Methyl-bis(2-chloroethyl)amine; N-Methyl-bis(beta-chloroethyl)amine; Beta,beta'-Dichlorodiethyl-N-methylamine; N-Methyl-2,2'-dichlorodiethylamine; N,N-Bis(2-chloroethyl)-N-methylamine; 1,5-Dichloro-3-methyl-3-azapentane hydrochloride; 2,2'-Dichloro-N-me; 2,2'-Dichloro-N-methyldiethylamine; 2,2'-Dichlorodiethyl-methylamine; 2-Chloro-N-(2-chloroethyl)-N-methylethanamine
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Drug Type |
Small molecular drug
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Indication | T-cell lymphoma [ICD-11: 2A90; ICD-10: C81-C86] | Approved | [1] | |
Hodgkin lymphoma [ICD-11: 2B30; ICD-10: C81, C81.9] | Phase 3 | [1], [2] | ||
Therapeutic Class |
Anticancer Agents
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Company |
Recordati Rare Diseases Inc
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Structure |
Download2D MOL |
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Formula |
C5H11Cl2N
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Canonical SMILES |
CN(CCCl)CCCl
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InChI |
1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3
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InChIKey |
HAWPXGHAZFHHAD-UHFFFAOYSA-N
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CAS Number |
CAS 51-75-2
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PubChem Compound ID | ||||
PubChem Substance ID |
9326, 219855, 3135533, 4782132, 7979875, 8149406, 8152524, 10524984, 11335934, 11361173, 11363783, 11366345, 11368907, 11371547, 11374586, 11377069, 11446034, 11462145, 11484232, 11488264, 11490300, 11492739, 11494703, 14772371, 17487142, 26611800, 26679305, 26747396, 26747397, 26747398, 29223144, 37217007, 46505784, 47291165, 47440287, 47662312, 48414146, 48416200, 49857537, 50105642, 51048787, 51091973, 53788825, 57322104, 92124119, 92307214, 99299432, 99301847, 103165035, 104305234
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ChEBI ID |
CHEBI:28925
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ADReCS Drug ID | BADD_D01359 ; BADD_D01360 | |||
SuperDrug ATC ID |
L01AA05
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SuperDrug CAS ID |
cas=000051752
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Target and Pathway | Top | |||
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Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Intercalator | [3] |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7218). | |||
REF 3 | Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem Res Toxicol. 2009 Jun;22(6):1151-62. |
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