Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D05PLH
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| Former ID |
DIB013592
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| Drug Name |
Carisoprodol
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| Synonyms |
carisoprodol; 78-44-4; Isomeprobamate; Carisoprodate; Carisoprodatum; Isoprotane; Isobamate; Isoprothane; Carisoma; Sanoma; Isopropyl meprobamate; SOMA; Somalgit; Atonalyt; Mioratrina; Mioartrina; Flexartal; Skutamil; Miolisodal; Mioril; Apesan; Relasom; Nospasm; Flexal; Arusal; Somanil; Carlsoprol; Carisoprodolum; Domarax; Stialgin; Somadril; Carsodal; Mioriodol; Mediquil; Izoprotan; Isoprotan; Carisol; Caprodat; Calenfa; Diolene; Carlsoma; Carlsodol; Brianil; Flexidon; Flexagilt; Caridolin; Meprodat; Listaflex; Flexagit; Fibrosona; Chinchen; Carsodol
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| Drug Type |
Small molecular drug
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| Indication | Musculoskeletal disorder [ICD-11: FA00-FC0Z; ICD-10: M00-M99] | Approved | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H24N2O4
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| Canonical SMILES |
CCCC(C)(COC(=O)N)COC(=O)NC(C)C
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| InChI |
1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16)
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| InChIKey |
OFZCIYFFPZCNJE-UHFFFAOYSA-N
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| CAS Number |
CAS 78-44-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10129, 443963, 855912, 7387049, 7847833, 7978862, 8149234, 8151701, 10321151, 10535973, 11335991, 11361230, 11362956, 11365518, 11368080, 11371255, 11373869, 11376242, 11462202, 11466451, 11467571, 11484841, 11486081, 11488969, 11490144, 11492080, 11493916, 15392472, 17389120, 17404882, 24278083, 26611639, 26679844, 26747205, 26747206, 26752303, 29221736, 46506377, 47216818, 47365236, 47440305, 47440306, 47885452, 47885453, 48334536, 48334537, 48423090, 48424936, 49698682, 49855864
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| ChEBI ID |
CHEBI:3419
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| ADReCS Drug ID | BADD_D00370 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -0.59; p = 0.011). | |||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.566; p = 0.034). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.971; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.86; p = 0.021). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.663; p = 0.014). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.58; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.719; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.772; p = 0.019). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.694; p = 0.034). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.785; p = 0.029). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.558; p = 0.045). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.618; p = 0.033). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.56; p = 0.037). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.857; p = 0.016). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.977; p = 0.006). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.598; p = 0.006). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.706; p = 0.029). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.517; p = 0.022). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -0.437; p = 0.019). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.49; p = 0.035). | |||
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Studied Microbe: Clostridium sp.
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Carisoprodol can be metabolized by Clostridium sp. (log2FC = -0.501; p = 0.021). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7610). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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