Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D05RHI
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| Former ID |
DAP000760
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| Drug Name |
Trifluridine
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| Synonyms |
Fluridine; TFDU; TRIFLUOROTHYMIDINE; Trifluoridine; Trifluoromethyldeoxyuridine; Trifluridina; Trifluridinum; Virophta; Viroptic; Trifluorothymine deoxyriboside; CF3dUrd; F3DThd; F3T; F3TDR; HS-0007; Trifluridina [INN-Spanish]; Trifluridine [USAN:INN]; Trifluridinum [INN-Latin]; Viroptic (TN); Trifluridine (USP/INN);Viroptic, Trifluorothymidine, Trifluridine; Alpha,alpha,alpha-Trifluorothymidine; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione; 2'-Deoxy-5-(trifluoromethyl)uridine; 2'-Deoxy-5-trifluoromethyluridine; 5-(Trifluoromethyl)-2'-deoxyuridine; 5-(Trifluoromethyl)deoxyuridine; 5-Trifluoro-2'-deoxythymidine; 5-Trifluoromethyl-2'-deoxyuridine; 5-Trifluoromethyl-2-deoxyuridine; 5-Trifluorothymidine
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Approved | [1], [2] | |
| Therapeutic Class |
Antiviral Agents
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| Company |
Monarch Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H11F3N2O5
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| Canonical SMILES |
C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
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| InChI |
1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
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| InChIKey |
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
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| CAS Number |
CAS 70-00-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
626314, 7847457, 7980831, 8139891, 8153936, 12014784, 12149237, 14751529, 14849367, 24900027, 29225252, 46506192, 50054714, 56422883, 57323294, 77174799, 87560183, 93815015, 103321204, 104023317, 104253375, 104311541, 118048237, 124757493, 124800643, 125164297, 126667216, 129521334, 131404691, 134223275, 134338045, 134971818, 135681084, 135692274, 136369804, 137000771, 137005241, 137213977, 144205964, 152058901, 160963778, 163835390, 170464911, 172092201, 172919625, 174483143, 175266936, 175612130, 176484794, 179116934
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| ChEBI ID |
CHEBI:75179
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| ADReCS Drug ID | BADD_D02283 | |||
| SuperDrug ATC ID |
S01AD02
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| SuperDrug CAS ID |
cas=000070008
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8697). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074311. | |||
| REF 3 | Trifluorothymidine induces cell death independently of p53. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703. | |||
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