Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07BSQ
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| Former ID |
DIB005011
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| Drug Name |
Progesterone
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| Synonyms |
progesterone; 57-83-0; Agolutin; Pregn-4-ene-3,20-dione; Luteohormone; Crinone; 4-Pregnene-3,20-dione; Utrogestan; Syngesterone; Progestin; Luteol; Corpus luteum hormone; Progesterol; Progesteronum; Pregnenedione; Glanducorpin; Prometrium; Corlutin; Cyclogest; Progestron; Gestormone; Progestone; Gestone; Progestasert; Progestronol; Methylpregnone; Hormoflaveine; Syngestrets; Proluton; Progekan; Nalutron; Lutoform; Gynlutin; Gesterol; Fologenon; Corporin; Corlutina; Syntolutan; Prolidon; Membrettes; Lutocyclin; Luteodyn; Lucorteum; Corluvite; LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine
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| Drug Type |
Small molecular drug
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| Indication | Premature labour [ICD-11: JB00; ICD-10: O60] | Approved | [1], [2] | |
| Contraception [ICD-11: QA21] | Phase 3 | [3] | ||
| Company |
Lipocine Inc
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| Structure |
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Download2D MOL |
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| Formula |
C21H30O2
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
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| InChI |
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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| InChIKey |
RJKFOVLPORLFTN-LEKSSAKUSA-N
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| CAS Number |
CAS 57-83-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3700, 75083, 110315, 625872, 818903, 834065, 837053, 841781, 855688, 3139517, 6435812, 6436726, 6436727, 7847134, 7890619, 7980395, 8026442, 8144717, 8153728, 10318966, 10321434, 11446518, 11466505, 11467625, 11486289, 12015027, 14850243, 14874443, 17388760, 17389514, 17405453, 24278618, 24870355, 24898476, 24898649, 24898857, 24898978, 24899064, 25621439, 26715972, 26719639, 26746572, 26751485, 26751486, 26759395, 29204503, 29225009, 46386909, 46391718, 46392093
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| ChEBI ID |
CHEBI:17026
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| ADReCS Drug ID | BADD_D01852 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Metabolic Reaction | Reduction | |||
| Experimental Method | High-throughput screening | |||
| Description | Progesterone can be metabolized by gut microbiota through reduction. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Agonist | [5] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2377). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038483) | |||
| REF 3 | ClinicalTrials.gov (NCT00822900) Progesterone for the Treatment of Traumatic Brain Injury III. U.S. National Institutes of Health. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | Clinical pipeline report, company report or official report of lipocine. | |||
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