Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07FCV
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| Drug Name |
PMID27414413-Compound-Figure6right
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| Drug Type |
Small molecular drug
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| Company |
J-PHARMA CO., LTD. WEMPE, Michael, F. ENDOU, Hitoshi
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H12Br2O3
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| Canonical SMILES |
CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br
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| InChI |
1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
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| InChIKey |
WHQCHUCQKNIQEC-UHFFFAOYSA-N
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| CAS Number |
CAS 3562-84-3
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:3023
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium breve DSM 20213
Show/Hide Hierarchy
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[1] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Benzbromarone can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -1.828; p = 0.049). | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Benzbromarone (adjusted p-values: 1.61E-04). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Benzbromarone (adjusted p-values: 2.63E-03). | |||
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Studied Microbe: Bacteroides ovatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Benzbromarone (adjusted p-values: 1.23E-03). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Benzbromarone (adjusted p-values: 3.23E-04). | |||
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Studied Microbe: Bacteroides uniformis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Benzbromarone (adjusted p-values: 7.82E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Benzbromarone (adjusted p-values: 2.26E-03). | |||
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Studied Microbe: Odoribacter splanchnicus
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Benzbromarone (adjusted p-values: 1.01E-05). | |||
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Studied Microbe: Parabacteroides distasonis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Benzbromarone (adjusted p-values: 4.82E-06). | |||
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Studied Microbe: Parabacteroides merdae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Benzbromarone (adjusted p-values: 5.90E-05). | |||
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Studied Microbe: Prevotella copri
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Benzbromarone (adjusted p-values: 2.19E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Benzbromarone (adjusted p-values: 4.15E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Benzbromarone (adjusted p-values: 4.13E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Benzbromarone (adjusted p-values: 4.51E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Benzbromarone (adjusted p-values: 1.97E-06). | |||
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Studied Microbe: Clostridioides difficile
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Benzbromarone (adjusted p-values: 3.08E-05). | |||
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Studied Microbe: Clostridium perfringens
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Benzbromarone (adjusted p-values: 7.48E-07). | |||
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Studied Microbe: Coprococcus comes
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Benzbromarone (adjusted p-values: 7.60E-04). | |||
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Studied Microbe: Enterocloster bolteae
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Benzbromarone (adjusted p-values: 8.20E-05). | |||
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Studied Microbe: Eubacterium rectale
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Benzbromarone (adjusted p-values: 3.86E-03). | |||
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Studied Microbe: Lacrimispora saccharolytica
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Benzbromarone (adjusted p-values: 2.64E-04). | |||
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Studied Microbe: Roseburia intestinalis
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Benzbromarone (adjusted p-values: 6.44E-03). | |||
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Studied Microbe: Ruminococcus bromii
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Benzbromarone (adjusted p-values: 7.42E-05). | |||
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Studied Microbe: Ruminococcus gnavus
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Benzbromarone (adjusted p-values: 2.26E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Benzbromarone (adjusted p-values: 7.17E-03). | |||
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Studied Microbe: Streptococcus parasanguinis
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Benzbromarone (adjusted p-values: 1.00E-04). | |||
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Studied Microbe: Streptococcus salivarius
Show/Hide Hierarchy
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Benzbromarone (adjusted p-values: 5.04E-06). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Urate anion exchanger 1 (URAT1) | Target Info | Inhibitor | [3] |
| Target's Patent Info | Urate anion exchanger 1 (URAT1) | Target's Patent Info | [3] | |
| WikiPathways | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. | |||
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