Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07HQC
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| Drug Name |
Modafinil
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| Synonyms |
Provigil; Modiodal
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| Drug Type |
Small molecular drug
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| Indication | Narcolepsy [ICD-11: 7A20; ICD-10: G47.4; ICD-9: 347] | Approved | [1] | |
| Bipolar disorder [ICD-11: 6A60; ICD-10: F31] | Phase 4 | [2] | ||
| Brain injury [ICD-11: NA07.Z] | Investigative | [3] | ||
| Therapeutic Class |
Neurology Agents
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| Company |
Cephalon Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H15NO2S
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| Canonical SMILES |
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
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| InChI |
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
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| InChIKey |
YFGHCGITMMYXAQ-UHFFFAOYSA-N
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| CAS Number |
CAS 68693-11-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:77585
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| ADReCS Drug ID | BADD_D01484 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Modulator | [4] |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | ClinicalTrials.gov (NCT01965925) Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil. U.S. National Institutes of Health. | |||
| REF 3 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
| REF 4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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