Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07KEH
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| Former ID |
DIB005678
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| Drug Name |
AKB-6548
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| Indication | Anaemia [ICD-11: 3A90; ICD-10: D64.8] | Phase 3 | [1] | |
| Company |
Akebia therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H11ClN2O4
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| Canonical SMILES |
C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
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| InChI |
1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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| InChIKey |
JGRXMPYUTJLTKT-UHFFFAOYSA-N
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| CAS Number |
CAS 1000025-07-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HIF-prolyl hydroxylase (HPH) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03242967) Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) (TRILOGY). U.S. National Institutes of Health. | |||
| REF 2 | DOI: 10.1038/nrd4422 | |||
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