Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07MIE
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| Former ID |
DIB021119
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| Drug Name |
UDP-glucose
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| Synonyms |
Uridine-5'-diphosphate-glucose; URIDINE DIPHOSPHATE GLUCOSE; UDPG; UDP-alpha-D-Glucose; 133-89-1; UNII-V50K1D7P4Y; URIDINE-5'-DIPHOSPHATE-GLUCOSE; 5'-Diphosphoglucose; UDP-D-glucose; GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE; UDPglucose; V50K1D7P4Y; CHEBI:46229; URIDINE-5'-DIPHOSPHOGLUCOSE; UDP-Glc; Uridine diphosphoglucose; Uridine 5'-diphosphoglucose; co-waldenase; URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER; co-galactoisomerase; [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]; uridine diphosphate glucose; Glucose-Uridine-C1,5'-Diphosphate
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C15H24N2O17P2
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| Canonical SMILES |
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)CO)O)O)O)O)O
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| InChI |
1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
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| InChIKey |
HSCJRCZFDFQWRP-JZMIEXBBSA-N
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| CAS Number |
CAS 133-89-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3331, 822334, 822339, 822342, 822373, 822736, 823181, 825775, 825937, 826789, 826790, 828077, 828078, 831215, 832419, 833448, 838338, 841583, 855084, 855419, 855421, 7888026, 7891010, 8010109, 8015887, 8026467, 8156098, 11532689, 11538176, 14813015, 24277414, 26702312, 26707743, 26707752, 26707756, 26707760, 26712884, 26713096, 26737026, 26750306, 29227297, 49655449, 49655451, 50086969, 50092239, 57325140, 57581424, 74382948, 77612458, 85149417
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| ChEBI ID |
CHEBI:46229
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2Y purinoceptor 14 (P2RY14) | Target Info | Agonist | [3] |
| UDP-glucose 4-epimerase (GALE) | Target Info | Inhibitor | [1] | |
| Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) | Target Info | Agonist | [4] | |
| BioCyc | D-galactose degradation V (Leloir pathway) | |||
| UDP-N-acetyl-D-galactosamine biosynthesis I | ||||
| UDP-N-acetyl-D-galactosamine biosynthesis II | ||||
| KEGG Pathway | Galactose metabolism | |||
| Amino sugar and nucleotide sugar metabolism | ||||
| Metabolic pathways | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Fructose galactose metabolism | |||
| Pathwhiz Pathway | Nucleotide Sugars Metabolism | |||
| Galactose Metabolism | ||||
| WikiPathways | Metabolism of carbohydrates | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1783). | |||
| REF 3 | Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8. | |||
| REF 4 | The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. | |||
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