Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07SOO
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| Former ID |
DAP000682
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| Drug Name |
Methoxyflurane
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| Synonyms |
Analgizer; Anecotan; Ingalan; Inhalan; Methofane; Methoflurane; Methofluranum; Methoxane; Methoxiflurane; Methoxifluranum;Methoxyfluoran; Methoxyfluorane; Methoxyfluran; Methoxyfluranum; Metofane; Metossiflurano; Metoxfluran; Metoxifluran; Metoxiflurano; Penthrane; Pentran; Pentrane; Metossiflurano [DCIT]; Methoxyflurane [Anaesthetics, volatile]; Methoxyfluranum [INN-Latin]; Metofane (VAN); Metoxiflurano [INN-Spanish]; Penthrane (TN); Penthrane (VAN); Methoxyflurane (USP/INN); Methoxyflurane [USAN:INN:BAN]; Methyl 1,1-difluoro-2,2-dichloroethyl ether; Ether, 2,2-dichloro-1,1-difluoroethyl methyl; (2,2-dichloro-1,1-difluoroethyl) methyl ether; 2,2-Dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether
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| Drug Type |
Small molecular drug
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| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Approved | [1], [2] | |
| Therapeutic Class |
Anesthetics
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| Structure |
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Download2D MOL |
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| Formula |
C3H4Cl2F2O
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| Canonical SMILES |
COC(C(Cl)Cl)(F)F
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| InChI |
1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3
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| InChIKey |
RFKMCNOHBTXSMU-UHFFFAOYSA-N
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| CAS Number |
CAS 76-38-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9720, 409141, 3219845, 7666803, 7847610, 8152583, 10535151, 12055768, 14772496, 29223224, 46508879, 48423662, 49855814, 50113268, 50702824, 57309755, 57322151, 103427852, 104305473, 117484889, 117650907, 118838651, 125374192, 129121548, 131498568, 132511622, 134337971, 134971540, 135586124, 136987072, 137004982, 143456706, 143799541, 144206179, 160964363, 162765240, 163788948, 164812131, 176318772, 178103808, 179225909, 184554813, 187072658, 198981352, 202542063, 204417825, 223439742, 226492719, 241138142, 249944760
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| ChEBI ID |
CHEBI:6843
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| SuperDrug ATC ID |
N02BG09
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| SuperDrug CAS ID |
cas=000076380
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Antagonist | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7234). | |||
| REF 2 | Drug information of Methoxyflurane, 2008. eduDrugs. | |||
| REF 3 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. | |||
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