Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07TWN
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| Former ID |
DNCL003587
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| Drug Name |
Tafenoquine
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| Synonyms |
106635-80-7; WR-238605; WR 238605; Etaquine; WR238605; Tafenoquine [INN:BAN
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Plasmodium vivax malaria [ICD-11: 1F41] | Approved | [1] | ||
| Company |
Medicines for Malaria Venture/GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C24H28F3N3O3
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| Canonical SMILES |
CC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OC
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| InChI |
1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3
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| InChIKey |
LBHLFPGPEGDCJG-UHFFFAOYSA-N
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| CAS Number |
CAS 106635-80-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:141487
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Electron transport complex III (Complex III) | Target Info | Inhibitor | [1] |
| Reactive oxygen species (ROS) | Target Info | Modulator | [1] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523. | |||
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