Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08FTG
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| Former ID |
DAP000769
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| Drug Name |
Phenindione
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| Synonyms |
Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan; Dineval; Diophindane; Emandion; Emandione; Eridione; Fenhydren; Fenilin; Fenindion; Fenindiona; Hedulin; Hemolidione; Indema; Indion; Indon; Phenhydren; Phenillin; Phenindionum; Phenylen; Phenylin; Phenylindanedione; Phenylindione; Phenyline; Phenyllin; Pindione; Rectadione; Theradione; Thrombasal; Tromazal; Trombol; Boots Brand of Phenindione; Goldshield Brand of Phenindione; Merck Lipha Sante Brand of Phenindione; P1029; P26406_ALDRICH; Fenindiona [INN-Spanish]; Hedulin (TN); Phenindione (INN); Phenindione [INN:BAN]; Phenindionum [INN-Latin]; 2 Phenyl 1,3 indandione; 2-Fenyloindandion-1,3; 2-Fenyloindandion-1,3 [Polish]; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione; 2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindan-1,3-dione; 2-Phenylindandione; 2-phenyl-1,3(2H)-Indenedione; 2-phenyl-2,3-dihydro-1H-indene-1,3-dione; 2-phenylindene-1,3-dione
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| Drug Type |
Small molecular drug
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| Indication | Coagulation defect [ICD-11: 3B10.0] | Approved | [1], [2], [3] | |
| Pulmonary embolism [ICD-11: BB00; ICD-10: I26, I26.0] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Anticoagulants
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| Structure |
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Download2D MOL |
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| Formula |
C15H10O2
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| Canonical SMILES |
C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
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| InChI |
1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
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| InChIKey |
NFBAXHOPROOJAW-UHFFFAOYSA-N
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| CAS Number |
CAS 83-12-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9786, 96470, 592770, 3140660, 4437707, 7980289, 8145933, 8149475, 8152921, 10321812, 10536726, 11112218, 11335482, 11360721, 11363821, 11366383, 11368945, 11371819, 11374091, 11377107, 11461693, 11466566, 11467686, 11484833, 11486212, 11488815, 11490526, 11492291, 11494741, 11532881, 14797982, 24898344, 26611868, 26679622, 26748198, 26748199, 28325577, 29223844, 46505018, 47365097, 47365098, 47588902, 47662190, 47662191, 48110361, 48184902, 48334394, 48416412, 49698721, 49982286
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| ChEBI ID |
CHEBI:8066
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| SuperDrug ATC ID |
B01AA02
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| SuperDrug CAS ID |
cas=000083125
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridium perfringens
Show/Hide Hierarchy
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Phenindione (adjusted p-values: 9.41E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vitamin K epoxide reductase complex 1 (VKORC1) | Target Info | Inhibitor | [5] |
| KEGG Pathway | Ubiquinone and other terpenoid-quinone biosynthesis | |||
| Pathwhiz Pathway | Vitamin K Metabolism | |||
| Coagulation | ||||
| WikiPathways | PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6838). | |||
| REF 2 | Drug information of Phenindione, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | [Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036. | |||
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