Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08RBC
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| Former ID |
DAP000741
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| Drug Name |
Escitalopram
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| Synonyms |
Esertia; Escitalopram [INN]; Cipralex (TN); Escitalopram (INN); Esertia (TN); Lexapro (TN); S(+)-Citalopram; (+)-(S)-1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; (S)-Citalopram
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2; ICD-9: 296.2, 296.3] | Approved | [1] | |
| Therapeutic Class |
Antidepressants
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| Company |
Forest Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H21FN2O
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| Canonical SMILES |
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
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| InChI |
1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
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| InChIKey |
WSEQXVZVJXJVFP-FQEVSTJZSA-N
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| CAS Number |
CAS 128196-01-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10249284, 11110983, 11114081, 11364295, 11366857, 11369419, 11371963, 11374782, 11377581, 11484357, 11488367, 11490877, 11493026, 11495215, 14777200, 14826334, 17425394, 46223778, 46507040, 47736762, 48185248, 50067335, 50100207, 50123207, 57346404, 80123692, 85789669, 92308964, 93167153, 96024609, 103558387, 104156586, 104414365, 124879737, 124879740, 126525322, 126626833, 126667435, 126669969, 127339776, 127339777, 127339778, 135103622, 137002472, 141023772, 141191354, 160964509, 163124265, 164834640, 172914696
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| ChEBI ID |
CHEBI:36791
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| ADReCS Drug ID | BADD_D00809 ; BADD_D00810 | |||
| SuperDrug ATC ID |
N06AB10
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| SuperDrug CAS ID |
cas=128196010
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serotonin transporter (SERT) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Antidepressants and sleep: a review. Perspect Psychiatr Care. 2009 Jul;45(3):191-7. | |||
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