Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09YHJ
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| Former ID |
DAP000261
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| Drug Name |
Ivermectin
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| Synonyms |
I 8898; Ivexterm (TN); MK-933; Mectizan (TN); Stromectol (TN)
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| Drug Type |
Small molecular drug
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| Indication | Intestinal strongyloidiasis due to nematode parasite [ICD-11: 1F6B; ICD-9: 127.2] | Approved | [1], [2] | |
| Therapeutic Class |
Antiprotozoal Agents
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| Company |
Merck & Co
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| Structure |
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Download2D MOL
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| Formula |
C48H74O14
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| Canonical SMILES |
CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
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| InChI |
1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
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| InChIKey |
AZSNMRSAGSSBNP-XPNPUAGNSA-N
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| CAS Number |
CAS 71827-03-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:63941
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| ADReCS Drug ID | BADD_D01221 | |||
| SuperDrug ATC ID |
P02CF01
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| SuperDrug CAS ID |
cas=070288867
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
|
Studied Microbe: Eubacterium rectale
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Ivermectin (adjusted p-values: 3.40E-03). | |||
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Studied Microbe: Roseburia intestinalis
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Ivermectin (adjusted p-values: 8.70E-04). | |||
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Studied Microbe: Ruminococcus torques
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Ivermectin (adjusted p-values: 4.51E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Ivermectin (adjusted p-values: 6.10E-03). | |||
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Studied Microbe: Streptococcus salivarius
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|
[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Ivermectin (adjusted p-values: 2.48E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Onchocerca Glutamate-gated chloride channel (Onchoc GluCl) | Target Info | Activator | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2373). | |||
| REF 2 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Inhibitory neurotransmission and olfactory memory in honeybees. Neurobiol Learn Mem. 2008 Nov;90(4):589-95. | |||
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