Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A8ZM
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Former ID |
DNC001253
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Drug Name |
S-(2-boronoethyl)-L-cysteine
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Synonyms |
S-(2-Boronoethyl)-L-cysteine; 63107-40-4; L-Cysteine, S-(2-boronoethyl)-; (2R)-2-amino-3-{[2-(dihydroxyboranyl)ethyl]sulfanyl}propanoic acid; C5H12BNO4S; SCHEMBL439378; GTPL5264; CHEBI:59346; CTK2F2710; DTXSID00432180; MolPort-039-139-054; HMS3648G13; 1633AH; AKOS006284223; ZINC195750889; S-[2-(dihydroxyboryl)ethyl]-L-cysteine; SR-01000946213; SR-01000946213-1; (R)-2-Amino-3-((2-boronoethyl)thio)propanoic acid; (2R)-2-amino-3-{[2-boronoethyl]thio}propanoic acid; (2R)-2-amino-3-{[2-boronoethyl]sulfanyl}propanoic acid; S-2-(Boronoethyl)-L-Cysteine
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C5H12BNO4S
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Canonical SMILES |
B(CCSCC(C(=O)O)N)(O)O
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InChI |
1S/C5H12BNO4S/c7-4(5(8)9)3-12-2-1-6(10)11/h4,10-11H,1-3,7H2,(H,8,9)/t4-/m0/s1
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InChIKey |
OTJHLDXXJHAZTN-BYPYZUCNSA-N
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CAS Number |
CAS 63107-40-4
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:59346
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Target and Pathway | Top | |||
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Target(s) | Kidney-type arginase (ARG2) | Target Info | Inhibitor | [2], [3] |
KEGG Pathway | Arginine and proline metabolism | |||
Metabolic pathways | ||||
Biosynthesis of antibiotics | ||||
Biosynthesis of amino acids | ||||
Amoebiasis | ||||
NetPath Pathway | TCR Signaling Pathway | |||
WikiPathways | Urea cycle and metabolism of amino groups | |||
Metabolism of amino acids and derivatives |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5264). | |||
REF 2 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
REF 3 | Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. |
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