Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B4RU
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| Former ID |
DIB016240
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| Drug Name |
Pregnenolone
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| Synonyms |
Pregnenolone (schizophrenia); Neurosteroid (schizophrenia), Neuroscience; Pregnenolone (schizophrenia), Neuroscience
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Phase 4 | [1], [2] | |
| Company |
Duke University
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| Structure |
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Download2D MOL |
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| Formula |
C21H32O2
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
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| InChI |
1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
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| InChIKey |
ORNBQBCIOKFOEO-QGVNFLHTSA-N
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| CAS Number |
CAS 145-13-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3095, 5056, 841801, 3136425, 7847211, 7889910, 8143499, 8156371, 10321800, 11466574, 11467694, 11486248, 12157331, 14850333, 24702313, 24887880, 24899008, 25621392, 29227585, 46506718, 47275669, 47646662, 48094643, 48318548, 48394039, 49698547, 50019742, 50111369, 50952978, 53790378, 56463239, 57325339, 85165262, 87574922, 90451278, 92125557, 92298073, 92309191, 92712002, 93167037, 93576762, 103557063, 103845983, 103914285, 104319171, 121363228, 124812051, 124892396, 126630318, 126656995
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| ChEBI ID |
CHEBI:16581
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Agonist | [3] |
| Reactome | PPARA activates gene expression | |||
| Transcriptional activation of mitochondrial biogenesis | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mitochondrial Gene Expression | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2376). | |||
| REF 2 | ClinicalTrials.gov (NCT01409096) Study Using Pregnenolone to Treat Bipolar Depression. U.S. National Institutes of Health. | |||
| REF 3 | Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6. | |||
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