Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B7OD
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| Former ID |
DAP001452
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| Drug Name |
Amfepramone
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| Synonyms |
Diethylpropion; DIETHYLPROPION; Diethylpropione; Amfepramon; Tepanil; Anorex; Nopropiophenone; Frekentine; Amphepramon; Amfepramonum; Amphepramone; Adiposon; Tylinal; Magrene; Dobesin; Neobes; Danylen; alpha-Benzoyltriethylamine; Anfepramona; Cegramine; Obesitex; Silutin; Regenon; Prefamone; Derfon; alpha-Diethylaminopropiophenone; 90-84-6; Diethylcathinone; Amfepramonum [INN-Latin]; Anfepramona [INN-Spanish]; Amfepramone [INN]; Parabolin; Modulor; Keramik; Keramin; Anfamon; 2-(Diethylamino)propiophenone; 1-Phenyl-2-diethylamino-1-propanone; Adiposon; Danylen;Derfon; Phepranon; Reginon; Amfepramone HCL; Amfepramone hydrochloride; Amphepramonum hydrochloride; Diethylpropion HCL; Diethylpropione hydrochloride; Tenuate hydrochloride; UR 1423; Alpha-Benzoyltriethylamine; Alpha-Diethylaminopropiophenone; Amfepramone (INN); Diethylpropion (BAN); Fenyl-(1-diethylaminoethyl)keton; Fenyl-(1-diethylaminoethyl)keton [Czech]; (+-)-diethylpropion; 2-(Diethylamino)-1-phenyl-1-propanone; 2-(diethylamino)-1-phenylpropan-1-one; 2-Diethylaminopropiophenone
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9] | Approved | [1], [2] | |
| Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Approved | [3] | ||
| Structure |
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Download2D MOL |
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| Formula |
C13H19NO
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| Canonical SMILES |
CCN(CC)C(C)C(=O)C1=CC=CC=C1
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| InChI |
1S/C13H19NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11H,4-5H2,1-3H3
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| InChIKey |
XXEPPPIWZFICOJ-UHFFFAOYSA-N
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| CAS Number |
CAS 90-84-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9169, 7423973, 7979076, 8154628, 10537732, 15438771, 29225940, 46506622, 48415889, 50026103, 51091775, 57323894, 75750729, 92712255, 99319074, 104171409, 104313762, 126128656, 126408370, 126625720, 129753898, 134223602, 134338141, 134338651, 134971122, 136936798, 137021040, 160964276, 168991721, 176267120, 177749275, 178103736, 179151422, 226414949, 249966592, 252089217, 252089218, 252163992, 252164026
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| ChEBI ID |
CHEBI:4530
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| ADReCS Drug ID | BADD_D00662 ; BADD_D00663 | |||
| SuperDrug ATC ID |
A08AA03
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| SuperDrug CAS ID |
cas=000090846
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Norepinephrine transporter (NET) | Target Info | Inhibitor | [3], [4] |
| Serotonin transporter (SERT) | Target Info | Inhibitor | [3], [4] | |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| Adrenaline and noradrenaline biosynthesis | ||||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7161). | |||
| REF 2 | Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci. 2008 Apr;29(4):208-17. | |||
| REF 3 | Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. | |||
| REF 4 | Phentermine and anaesthesia. Anaesth Intensive Care. 2005 Aug;33(4):525-7. | |||
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