Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0BM5G
|
|||
| Former ID |
DAP000462
|
|||
| Drug Name |
Tazarotene
|
|||
| Synonyms |
Avage; Suretin; Tazaroteno; Tazarotenum; Tazorac; Tazoral; Zorac; AGN 190168; AGN-190168; Avage (TN); Tazarotene [USAN:INN]; Tazorac (TN); Zorac (TN); Tazarotene (JAN/USAN/INN); Tazorac, Avage, Zora, Tazarotene; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate; Ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate; Ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester; 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-,ethyl ester
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Approved | [1], [2] | |
| Therapeutic Class |
Dermatologic Agents
|
|||
| Company |
Allergan Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C21H21NO2S
|
|||
| Canonical SMILES |
CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
|
|||
| InChI |
1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
|
|||
| InChIKey |
OGQICQVSFDPSEI-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 118292-40-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
582921, 4405151, 7848195, 8153307, 12014289, 14754274, 29224433, 46508992, 50031802, 50112778, 53789348, 56352905, 57322745, 68530738, 79123421, 85246194, 92719256, 93166451, 103629338, 104113517, 104253218, 104253308, 104309077, 124757343, 125164147, 125338838, 126620953, 126658167, 126670670, 127300883, 127300884, 127300885, 127300886, 127300887, 127300888, 127300889, 127300890, 127300891, 127300892, 127300893, 127300894, 127300895, 127300896, 127300897, 128806208, 134337757, 135017550, 135692178, 136376512, 136946544
|
|||
| ChEBI ID |
CHEBI:32184
|
|||
| ADReCS Drug ID | BADD_D02120 | |||
| SuperDrug ATC ID |
D05AX05
|
|||
| SuperDrug CAS ID |
cas=118292403
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor gamma (RARG) | Target Info | Binder | [3] |
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6952). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.