Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0FX2Q
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| Former ID |
DIB012898
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| Drug Name |
Rifamycin
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| Synonyms |
Rifamycin SV; Rifamycin SV MMX; Rifamycin sodium; CB-01-11; Rifamycin (oral controlled-release, gastrointestinal-specific); Rifamycin (oral controlled-release, gastrointestinal-specific), Cosmo/Dr Falk/Santarus
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| Drug Type |
Small molecular drug
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| Indication | Diarrhea [ICD-11: ME05.1] | Approved | [1] | |
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99] | Phase 3 | [2], [3] | ||
| Company |
Cosmo Technologies
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| Structure |
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Download2D MOL |
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| Formula |
C37H47NO12
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| Canonical SMILES |
CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C
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| InChI |
1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
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| InChIKey |
HJYYPODYNSCCOU-ODRIEIDWSA-N
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| CAS Number |
CAS 6998-60-3
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:29673
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial RNA polymerase sigma factor SigA (Bact sigA) | Target Info | Modulator | [4] |
| Mycobacterium RNA polymerase (MycB RNAP) | Target Info | Inhibitor | [1] | |
| Staphylococcus Plastid RNA polymerase beta (Stap-coc rpoB) | Target Info | Modulator | [4] | |
| KEGG Pathway | Purine metabolism | |||
| Pyrimidine metabolism | ||||
| Metabolic pathways | ||||
| RNA polymerase | ||||
| Purine metabolism | ||||
| Pyrimidine metabolism | ||||
| Metabolic pathways | ||||
| RNA polymerase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4570). | |||
| REF 3 | ClinicalTrials.gov (NCT01142089) Study to Evaluate Safety and Efficacy of Rifamycin SV Multi-Matrix System (MMX) for the Treatment of Traveler's Diarrhea (TD). U.S. National Institutes of Health. | |||
| REF 4 | NCBI report | |||
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