Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I0RJ
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| Former ID |
DAP000187
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| Drug Name |
Amiloride
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| Synonyms |
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
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| Drug Type |
Small molecular drug
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| Indication | Congestive heart failure [ICD-11: BD10; ICD-10: I50; ICD-9: 428] | Approved | [1], [2] | |
| Therapeutic Class |
Diuretics
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| Company |
Tornett pharmaceutical
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| Structure |
 |
Download2D MOL |
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| Formula |
C6H8ClN7O
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| Canonical SMILES |
C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
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| InChI |
1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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| InChIKey |
XSDQTOBWRPYKKA-UHFFFAOYSA-N
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| CAS Number |
CAS 2609-46-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9039, 621650, 838821, 3182570, 5866713, 7885870, 8162159, 11110775, 11113372, 11120240, 11120728, 11121216, 11121637, 11122117, 11335357, 11360596, 11362706, 11362808, 11365268, 11365370, 11367830, 11367932, 11370683, 11370684, 11371426, 11373431, 11373683, 11375992, 11376094, 11461568, 11466035, 11467155, 11483872, 11485670, 11487934, 11490109, 11491947, 11493848, 14798141, 26751628, 26751629, 29284103, 46391861, 46508156, 46516430, 47217018, 47217019, 47291344, 47440507, 47440508
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| ChEBI ID |
CHEBI:2639
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| ADReCS Drug ID | BADD_D00105 | |||
| SuperDrug ATC ID |
C03DB01
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| SuperDrug CAS ID |
cas=002609463
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| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acid-sensing ion channel 1 (ASIC1) | Target Info | Modulator | [3] |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | Stimuli-sensing channels | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2421). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 070346. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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