Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0IX6I
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| Former ID |
DIB019642
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| Drug Name |
cortisone
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| Synonyms |
11-dehydro-17-hydroxycorticosterone; 17-hydroxy-11-dehydrocorticosterone
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| Drug Type |
Small molecular drug
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| Indication | Atopic dermatitis [ICD-11: EA80; ICD-10: L20; ICD-9: 691.8, 692.9] | Approved | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C21H28O5
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| Canonical SMILES |
CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
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| InChI |
1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
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| InChIKey |
MFYSYFVPBJMHGN-ZPOLXVRWSA-N
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| CAS Number |
CAS 53-06-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4024, 75082, 798261, 855981, 7978990, 8144744, 9377265, 10321233, 11446517, 11466301, 11467421, 11486101, 12209743, 15292905, 17404803, 24278304, 24702315, 26751582, 26751583, 30425976, 46386956, 47500591, 47647587, 47647588, 48095608, 48095609, 48394991, 48415817, 49698414, 49846266, 49956063, 50104218, 50104219, 50104220, 50887212, 51075909, 51092041, 53777346, 53786703, 53788586, 56313608, 56422112, 57393130, 57399996, 58097551, 81093216, 85788975, 87566331, 89850284, 90341612
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| ChEBI ID |
CHEBI:16962
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| ADReCS Drug ID | BADD_D00532 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Description | Cortisone can be metabolized by gut microbiota. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5171). | |||
| REF 2 | Synthesis and in vitro properties of dexamethasone 21-sulfate sodium as a colon-specific prodrug of dexamethasone. Drug Dev Ind Pharm. 2006 Mar;32(3):389-97. | |||
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