Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J6XC
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| Former ID |
DIB018046
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| Drug Name |
tiratricol
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| Synonyms |
TRIAC; 3,3',5-triiodothyroacetic acid
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| Drug Type |
Small molecular drug
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| Indication | Wound healing [ICD-11: EL8Y] | Clinical trial | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C14H9I3O4
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| Canonical SMILES |
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O
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| InChI |
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
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| InChIKey |
UOWZUVNAGUAEQC-UHFFFAOYSA-N
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| CAS Number |
CAS 51-24-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
827844, 827845, 827846, 827962, 855525, 4401016, 7885356, 8153574, 10321449, 11112109, 11466230, 11467350, 11485840, 14912191, 24900466, 26737090, 26737092, 26737109, 26737501, 29224836, 46504696, 46518914, 47349482, 47943909, 48019053, 48094654, 48426110, 49698385, 50100372, 50610406, 51091552, 53788806, 56261036, 57322967, 57654700, 85756745, 85788050, 91722578, 92125149, 103219116, 103913943, 104310301, 119526441, 121362089, 121362820, 124772192, 124881906, 124881907, 124881908, 126408229
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyroid hormone receptor alpha (THRA) | Target Info | Agonist | [2] |
| Thyroid hormone receptor beta (THRB) | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Thyroid hormone signaling pathway | ||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Endochondral Ossification | |||
| Nuclear Receptors | ||||
| SIDS Susceptibility Pathways | ||||
| Hematopoietic Stem Cell Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2637). | |||
| REF 2 | Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. | |||
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