Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0KD1U
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| Former ID |
DAP000940
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| Drug Name |
Practolol
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| Synonyms |
Dalzic; Eraldin; Practololo; Practololum; Praktololu; Teranol; Eralzdin Practolol; Practololo [DCIT]; Praktololu [Polish]; AY 21011; Cardiol (TN); Cordialina (TN); Dalzic (TN); Eraldin (TN); Eraldina (TN); Practololum [INN-Latin]; Praktol (TN); Pralon (TN); Teranol (TN); Practolol [USAN:BAN:INN]; N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide; N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; N-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide; N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide; (+-)-Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
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| Drug Type |
Small molecular drug
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| Indication | Cardiac arrhythmias [ICD-11: BC9Z; ICD-9: 427] | Approved | [1], [2] | |
| Therapeutic Class |
Antiarrhythmic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C14H22N2O3
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| Canonical SMILES |
CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O
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| InChI |
1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
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| InChIKey |
DURULFYMVIFBIR-UHFFFAOYSA-N
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| CAS Number |
CAS 6673-35-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13861, 4500647, 7979385, 8150016, 8153002, 10321694, 11336076, 11361315, 11364348, 11366910, 11369472, 11374635, 11377634, 11462287, 11466360, 11467480, 11485240, 11486020, 11489388, 11492674, 11495268, 15197223, 26679880, 26751910, 26980600, 29223962, 46507496, 47207250, 47440331, 47959823, 48185058, 48259303, 48334570, 48334571, 48334572, 48414361, 49698824, 49860734, 50104588, 56413037, 56463034, 57322502, 80701653, 85209244, 85451356, 85788851, 87660772, 92125329, 92308845, 99301989
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| ChEBI ID |
CHEBI:258351
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| SuperDrug ATC ID |
C07AB01
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| SuperDrug CAS ID |
cas=006673354
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Antagonist | [2], [3] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 555). | |||
| REF 2 | Prostaglandin E2 synthesis elicited by adrenergic stimuli in guinea pig trachea is mediated primarily via activation of beta 2 adrenergic receptors. Prostaglandins. 1992 Nov;44(5):399-412. | |||
| REF 3 | TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. | |||
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