Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LM4A
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| Former ID |
DAP000265
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| Drug Name |
Varenicline
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| Synonyms |
CP 526555; Champix (TN); Chantix (TN); Varenicline (INN); 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine; 7,8,9,10-tetrahydro-6h-6,10-methanoazepino[4,5-g]quinoxaline
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| Drug Type |
Small molecular drug
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| Indication | Smoking dependence [ICD-11: 6C4A.2; ICD-10: F17.2; ICD-9: 292] | Approved | [1], [2] | |
| Company |
Pfizer Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C13H13N3
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| Canonical SMILES |
C1C2CNCC1C3=CC4=NC=CN=C4C=C23
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| InChI |
1S/C13H13N3/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1/h1-2,4-5,8-9,14H,3,6-7H2
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| InChIKey |
JQSHBVHOMNKWFT-UHFFFAOYSA-N
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| CAS Number |
CAS 249296-44-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D02337 ; BADD_D02338 | |||
| SuperDrug ATC ID |
N07BA03
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5459). | |||
| REF 2 | 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. | |||
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