Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M4XY
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| Former ID |
DNAP001268
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| Drug Name |
Omacetaxine mepesuccinate
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| Synonyms |
Synribo (TN)
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| Drug Type |
Small molecular drug
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| Indication | Chronic myeloid leukaemia [ICD-11: 2A20; ICD-10: C91-C95; ICD-9: 208.9] | Approved | [1], [2] | |
| Company |
Ivax
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| Structure |
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Download2D MOL |
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| Formula |
C29H39NO9
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| Canonical SMILES |
CC(C)(CCCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
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| InChI |
1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
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| InChIKey |
HYFHYPWGAURHIV-JFIAXGOJSA-N
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| CAS Number |
CAS 26833-87-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
427112, 8869174, 11114076, 11405312, 12013050, 14788079, 14837137, 34825849, 46386877, 46391339, 49681783, 57401116, 79108019, 85788654, 91746329, 96025639, 103227500, 103842884, 104468988, 117552215, 119501491, 124557941, 124887020, 124887021, 124887022, 137263843, 138369330, 152186840, 160646235, 162022912, 162187591, 162225377, 162264064, 163123532, 163614705, 172080518, 175266169, 179349289, 187051757, 198993044, 202284495, 204377859, 210275165, 210280805, 221222480, 223384776, 237779974, 241182412, 241375418, 251885344
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| ChEBI ID |
CHEBI:71019
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| ADReCS Drug ID | BADD_D01609 | |||
| SuperDrug ATC ID |
L01XX40
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ribosome A (hRA) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7454). | |||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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