Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q5SL
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| Former ID |
DNC001654
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| Drug Name |
BRL54443
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| Synonyms |
57477-39-1; BRL 54443; BRL-54443; 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol; BRL54443; UNII-Q2DH1CHI0Y; Q2DH1CHI0Y; 1H-Indol-5-ol, 3-(1-methyl-4-piperidinyl)-; 5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole; 3-(1-METHYL-4-PIPERIDINYL)-1H-INDOL-5-OL; AK163730; NCGC00015134-01; Tocris-1129; Lopac-B-173; AC1L1DOE; Biomol-NT_000107; Lopac0_000207; ZINC7339; BPBio1_001401; SCHEMBL3546728; GTPL3927; CHEMBL1371156; CTK6I2277; CHEBI:92321; KS-00000SOT; QCR-209; DTXSID40206089; WKNFADCGOAHBPG-UHFFFAOYSA-N; MolPort-021-804-935; BCPP000316
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H18N2O
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| Canonical SMILES |
CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)O
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| InChI |
1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3
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| InChIKey |
WKNFADCGOAHBPG-UHFFFAOYSA-N
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| CAS Number |
CAS 57477-39-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5580999, 8151627, 11110825, 11113936, 15220671, 26752089, 29221602, 47365411, 47440474, 48185186, 50104743, 77824568, 85208985, 90341506, 104300587, 124749544, 124879371, 124879372, 124879373, 125093101, 125568956, 129594833, 135698379, 136368024, 137005651, 144115754, 152344534, 162009742, 162023008, 162220574, 162957191, 164045135, 172648765, 178100756, 198966450, 210274835, 210280467, 216088069, 223380665, 223674589, 223702804, 223872422, 225362715, 229554251, 241182155, 242060374, 242181581, 249768037, 249860760, 250225738
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| ChEBI ID |
CHEBI:92321
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1E receptor (HTR1E) | Target Info | Agonist | [2] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3927). | |||
| REF 2 | Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. | |||
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