Drug Information
Drug General Information | Top | |||
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Drug ID |
D0S5LH
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Former ID |
DAP000562
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Drug Name |
Edrophonium
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Synonyms |
EDR; Edrophonum; Edroponium; Reversol; Tensilon; EDROPHONIUM ION; Edrophone Chloride; Enlon Plus; ENLON-PLUS; Enlon (TN); Reversol (TN); Tensilon (TN); Ethyl-(3-hydroxyphenyl)-dimethylazanium; Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium; N-ethyl-3-hydroxy-N,N-dimethylanilinium; N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium; (3-hydroxyphenyl)dimethylethylammonium; 3-hydroxy-N,N-dimethyl-N-ethylanilinium
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Drug Type |
Small molecular drug
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Indication | Myasthenia gravis [ICD-11: 8C6Y; ICD-9: 358] | Approved | [1] | |
Therapeutic Class |
Antidotes
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Structure |
Download2D MOL |
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Formula |
C10H16NO+
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Canonical SMILES |
CC[N+](C)(C)C1=CC(=CC=C1)O
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InChI |
1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
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InChIKey |
VWLHWLSRQJQWRG-UHFFFAOYSA-O
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CAS Number |
CAS 312-48-1
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PubChem Compound ID | ||||
PubChem Substance ID |
9190, 6212622, 7366196, 7887282, 7979147, 8152037, 11111143, 11111144, 11335984, 11361223, 11363336, 11365898, 11368460, 11374171, 11376622, 11462195, 11466111, 11467231, 11484956, 11485681, 11488926, 11492551, 11494256, 26702965, 26713721, 29222344, 46507530, 47365233, 47365234, 47515350, 47589038, 47662326, 47810792, 48035164, 48110488, 49698977, 50064671, 50100235, 50104222, 50923308, 53788287, 57321660, 58106942, 87350897, 90341680, 103812420, 103951705, 104234195, 104302825, 117617165
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ChEBI ID |
CHEBI:251408
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ADReCS Drug ID | BADD_D00747 ; BADD_D00748 |
Target and Pathway | Top | |||
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Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2], [3], [4] |
KEGG Pathway | Glycerophospholipid metabolism | |||
Cholinergic synapse | ||||
Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | ||||
Pathwhiz Pathway | Phospholipid Biosynthesis | |||
Pathway Interaction Database | ATF-2 transcription factor network | |||
WikiPathways | Monoamine Transport | |||
Biogenic Amine Synthesis | ||||
Acetylcholine Synthesis | ||||
Integrated Pancreatic Cancer Pathway |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040131. | |||
REF 2 | Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56. | |||
REF 3 | Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50. | |||
REF 4 | Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors. Biochemistry. 2009 Jan 27;48(3):563-74. |
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