Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0VF6E
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| Former ID |
DNC001102
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| Drug Name |
PD173074
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| Drug Type |
Small molecular drug
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| Indication | Nasopharyngeal carcinoma [ICD-11: 2B6B; ICD-9: 147] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C28H41N7O3
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| Canonical SMILES |
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
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| InChI |
1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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| InChIKey |
DXCUKNQANPLTEJ-UHFFFAOYSA-N
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| CAS Number |
CAS 219580-11-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
834654, 5359270, 7889759, 8035790, 8151133, 12015201, 14836471, 24439740, 24724575, 26758699, 29217621, 46394115, 49674688, 53790840, 57320895, 77522681, 99437062, 103102522, 103459751, 104297629, 117571944, 123220361, 124757129, 124800487, 124893193, 125163933, 125333800, 126731458, 131477697, 131480741, 134338999, 134340345, 134342600, 135352081, 135610525, 135686042, 135686043, 135686064, 135686065, 135698601, 136340183, 136367375, 136367834, 137183761, 139404141, 143496970, 144116352, 152234783, 152258172, 152344220
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| ChEBI ID |
CHEBI:63448
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| Drug Resistance Mutation (DRM) | Top | |||
|---|---|---|---|---|
| DRM | DRM Info | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.Cancer Biol Ther. 2014;15(12):1613-21. | |||
| REF 2 | Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024. | |||
| REF 3 | Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999;17(2):121-35. | |||
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