Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0X6GN
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| Former ID |
DAP001045
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| Drug Name |
Loteprednol Etabonate
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| Synonyms |
Alrex; Locort; Loteflam; Lotemax; Loterox; CDDD-5604; HGP-1; IDR-90102; IDR-90103; Lotemax (TN); P-5604; Alrex, Lotemax, Loteprednol etabonate; Loteprednol etabonate (JAN/USAN); Chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate; Chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
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| Drug Type |
Small molecular drug
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| Indication | Eye inflammation [ICD-11: 9A02; ICD-10: H00-H59; ICD-9: 360-379] | Approved | [1], [2] | |
| Therapeutic Class |
Antiallergic Agents
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| Company |
Bausch & Lomb Pharmaceuticals, Inc.
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H31ClO7
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| Canonical SMILES |
CCOC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C(=O)OCCl
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| InChI |
1S/C24H31ClO7/c1-4-30-21(29)32-24(20(28)31-13-25)10-8-17-16-6-5-14-11-15(26)7-9-22(14,2)19(16)18(27)12-23(17,24)3/h7,9,11,16-19,27H,4-6,8,10,12-13H2,1-3H3/t16-,17-,18-,19+,22-,23-,24-/m0/s1
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| InChIKey |
DMKSVUSAATWOCU-HROMYWEYSA-N
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| CAS Number |
CAS 82034-46-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7848752, 10299468, 12014581, 14809424, 14834133, 36887139, 46386647, 49681758, 53788349, 56352909, 57404592, 71824934, 74388043, 92308346, 103770848, 104253297, 104631159, 109692941, 124659028, 124757418, 124800193, 125164222, 126592942, 127755782, 134338307, 135014568, 135692220, 137023315, 140684370, 144205772, 152258757, 160647602, 160964214, 162179036, 164811824, 170465195, 172080414, 175266502, 176484705, 178103663, 179151237, 184664942, 226412422, 249850601, 252220094, 252359498
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| ChEBI ID |
CHEBI:31784
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| ADReCS Drug ID | BADD_D01324 | |||
| SuperDrug ATC ID |
S01BA14
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid hormone receptor ERR (ESRR) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7085). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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