Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Y5ZA
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| Former ID |
DNAP001376
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| Drug Name |
Arteether
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| Synonyms |
Beta arteether; Artecef (TN); Artemotil (TN)
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1], [2], [3] | |
| Company |
Artecef BV
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H28O5
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| Canonical SMILES |
CCOC1C(C2CCC(C3C24C(O1)OC(CC3)(OO4)C)C)C
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| InChI |
1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1
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| InChIKey |
NLYNIRQVMRLPIQ-XQLAAWPRSA-N
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| CAS Number |
CAS 75887-54-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:135335
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| SuperDrug ATC ID |
P01BE04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-hematin formation (BHF) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The role of natural product chemistry in drug discovery. J Nat Prod. 2004 Dec;67(12):2141-53. | |||
| REF 2 | Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins. Antimicrob Agents Chemother. 2012 May;56(5):2546-52. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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