Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0YO4D
|
|||
| Former ID |
DCL000277
|
|||
| Drug Name |
LG100268
|
|||
| Synonyms |
AmbkkkkK580; LG 100268; LG2; LG-100268; 6-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid; 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID; 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-nicotinic acid; 6-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Acquired immune deficiency syndrome [ICD-11: 1C62.3; ICD-9: 42] | Discontinued in Phase 1 | [1], [2] | |
| Company |
Ligand Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C24H29NO2
|
|||
| Canonical SMILES |
CC1=CC2=C(C=C1C3(CC3)C4=NC=C(C=C4)C(=O)O)C(CCC2(C)C)(C)C
|
|||
| InChI |
1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
|
|||
| InChIKey |
SLXTWXQUEZSSTJ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 153559-76-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
5569426, 7888633, 8152465, 14876979, 17396630, 26706533, 29223036, 46505129, 50032010, 53790477, 57322053, 74675773, 93167040, 93580484, 103147498, 103219924, 103941126, 104304910, 117420422, 119523768, 125738002, 126667021, 129255377, 134338934, 135221049, 135650517, 137061743, 137275854, 142528867, 160965165, 162275029, 162796208, 163780440, 164761581, 185963910, 198987930, 202545310, 204370195, 223660191, 223704975, 226641981, 242059770, 252215113, 252271908
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor alpha (RARA) | Target Info | Agonist | [3] |
| KEGG Pathway | Pathways in cancer | |||
| Transcriptional misregulation in cancer | ||||
| Acute myeloid leukemia | ||||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | |||
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Adipogenesis | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2808). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010920) | |||
| REF 3 | Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. Gen Comp Endocrinol. 2009 Sep 15;163(3):285-91. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.