Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z2LG
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| Former ID |
DNAP001633
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| Drug Name |
Sennoside a
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| Synonyms |
Sennoside A; 81-27-6; Senna extract; Senokot; UNII-2F1O30GVXH; EINECS 201-339-9; NSC 112929; 2F1O30GVXH; CHEBI:9112; 8013/11/4; sennoside; Senolax; Dosaflex; Glaxenna; Sennalax; Gentlax; Amyran; Exprep; Moivat; Senan; Sennae folium; Black Draught; Sennoside-A; NSC112929; Tisasen A; Senna (powdered); Sennoside A, G; NCGC00095095-01; GLYSENNIDE; SENNA; AC1L2JAB; DSSTox_CID_3576; Sennosides A + B 99%; DSSTox_RID_77089; DSSTox_GSID_23576; SCHEMBL440792; Ex-Lax Regular Strength Pills; MEGxp0_001902; CCRIS 7489; DTXSID1023576
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| Drug Type |
Small molecular drug
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| Indication | Cardiovascular disease [ICD-11: BA00-BE2Z; ICD-10: I00-I99] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C42H38O20
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| Canonical SMILES |
C1=CC2=C(C(=C1)OC3C(C(C(C(O3)CO)O)O)O)C(=O)C4=C(C2C5C6=C(C(=CC=C6)OC7C(C(C(C(O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
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| InChI |
1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
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| InChIKey |
IPQVTOJGNYVQEO-KGFNBKMBSA-N
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| CAS Number |
CAS 8013-11-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12590, 8195564, 29204569, 43129129, 47647936, 47796477, 48319960, 48416535, 48424071, 50065244, 57318953, 74382022, 76648574, 88785592, 92710593, 95155085, 103050102, 104354512, 126631718, 126658092, 135029096, 137249156, 144204973, 152099887, 160844978, 162183008, 163614553, 164178045, 164788470, 174500107, 179236259, 184534068, 184545276, 198972047, 198982903, 221672667, 223440964, 223682144, 226763509, 241146632, 251911802, 251914880, 252359100, 252402606, 252403605
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| ChEBI ID |
CHEBI:9112
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [2] | |||
| Microbial Enzyme | Reductase and 3- b-D-glucosidase | |||
| Metabolic Reaction | Reduction and deglycosylation | |||
| Resulting Metabolite | Sennidins | |||
| Metabolic Effect | Increase activity | |||
| Description | Sennosides can be metabolized to Sennidins by the reductase and 3- b-D-glucosidase of gut microbiota through reduction and deglycosylation, which results in the increase of the drug's activity. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Gut Microbiota-Mediated Drug-Antibiotic Interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9. | |||
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