Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z4XW
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| Former ID |
DAP001449
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| Drug Name |
Topetecan
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| Synonyms |
TOPOTECAN HYDROCHLORIDE; 119413-54-6; Topotecan Hcl; Hycamptamine hydrochloride; Topotecan (Hydrochloride); Topotecan monohydrochloride; UNII-956S425ZCY; Topotecan hydrochloride [USAN]; Nogitecan hydrochloride; DRG-0288; F S-104864-A; NSC-609699; NSC 609699; NSC609699; 956S425ZCY; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione monohydrochloride; NCGC00095189-01; AK-48920; DSSTox_RID_81248; DSSTox_CID_25952
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| Drug Type |
Small molecular drug
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| Indication | Small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162.9] | Approved | [1] | |
| Company |
GSK
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H24ClN3O5
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| Canonical SMILES |
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
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| InChI |
1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
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| InChIKey |
DGHHQBMTXTWTJV-BQAIUKQQSA-N
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| CAS Number |
CAS 119413-54-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
580652, 4254372, 7849229, 8187012, 12014351, 14808962, 14858018, 26612947, 26652314, 26719851, 26749084, 26749085, 43118055, 46386667, 49681835, 50064238, 50107520, 57314069, 77238590, 81043930, 91011865, 92124726, 92711334, 99437042, 103592348, 104133510, 104321413, 117451252, 118844639, 124635315, 124757103, 125163907, 126630966, 126657419, 126665399, 134338648, 135017834, 136340285, 136378525, 144075973, 144205031, 152039834, 160848176, 162037509, 162176905, 164194986, 164814890, 170465137, 172080300, 174474422
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| ADReCS Drug ID | BADD_D02249 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [2] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020671. | |||
| REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | |||
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