Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00EZE
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| Former ID |
DIB004442
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| Drug Name |
Panamesine
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| Synonyms |
EMD-57445; EMD-59983
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Discontinued in Phase 2 | [1] | |
| Company |
Merck KGaA
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H26N2O6
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| Canonical SMILES |
COC1=CC=C(C=C1)N2CC(OC2=O)CN3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O
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| InChI |
1S/C23H26N2O6/c1-28-18-5-3-17(4-6-18)25-14-19(31-22(25)26)13-24-10-8-23(27,9-11-24)16-2-7-20-21(12-16)30-15-29-20/h2-7,12,19,27H,8-11,13-15H2,1H3/t19-/m0/s1
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| InChIKey |
NINYZUDVKTUKIA-IBGZPJMESA-N
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| CAS Number |
CAS 139225-22-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Binder | [2], [3], [4] |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001428) | |||
| REF 2 | Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry. 1999 Mar;32(2):68-72. | |||
| REF 3 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | |||
| REF 4 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | |||
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