Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00FGV
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| Former ID |
DAP001069
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| Drug Name |
Carbinoxamine
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| Synonyms |
Allergefon; Carbinoxamina; Carbinoxaminum; Clistin; Clistine; Paracarbinoxamine; Paracarinoxamine; Rotoxamine; Carbinoxamine base; Carbinoxamina [INN-Spanish]; Carbinoxamine (INN); Carbinoxamine [INN:BAN]; Carbinoxaminum [INN-Latin]; Clistin (TN); McN-R 73Z; Palgic (TN); {2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine; N,N-Dimethyl-2-(p-chloro-alpha-(2-pyridyl)benzyloxy)ethylamine; Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-(9CI); (+-)-Carbinoxamine; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine; 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine; 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine; 2-{[(4-chlorophenyl)(pyridin-2-yl)methyl]oxy}-N,N-dimethylethanamine
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| Drug Type |
Small molecular drug
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| Indication | Vasomotor/allergic rhinitis [ICD-11: CA08; ICD-10: J30-J39, J30] | Approved | [1] | |
| Therapeutic Class |
Antihistamines
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| Company |
McNeil Laboratories
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| Structure |
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Download2D MOL |
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| Formula |
C16H19ClN2O
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| Canonical SMILES |
CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
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| InChI |
1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
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| InChIKey |
OJFSXZCBGQGRNV-UHFFFAOYSA-N
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| CAS Number |
CAS 486-16-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9088, 615221, 5051969, 7978860, 8151694, 10523882, 10527104, 11335994, 11361233, 11362934, 11365496, 11368058, 11371253, 11373867, 11376220, 11462205, 11466829, 11467949, 11484729, 11486318, 11488943, 11490143, 11492079, 11493914, 16888880, 29217899, 29221724, 46506787, 47515357, 47736528, 47885455, 48110489, 48110490, 48110491, 48185036, 48259277, 48415697, 49698846, 50032039, 50111737, 50111738, 51091926, 77851965, 85209627, 85788414, 87245633, 92721277, 92729945, 103224683, 104300953
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| ChEBI ID |
CHEBI:3398
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| ADReCS Drug ID | BADD_D00361 ; BADD_D00362 | |||
| SuperDrug ATC ID |
R06AA08
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| SuperDrug CAS ID |
cas=000486168
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Comparison of the effects of eleven histamine H1-receptor antagonists on monoamine turnover in the mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. | |||
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