Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00HWF
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| Former ID |
DNC002359
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| Drug Name |
Proxyfan
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| Synonyms |
Proxyfan; proxifan; 3-(1H-imidazol-4-yl)propylphenylmethyl ether; 1H-Imidazole, 5-[3-(phenylmethoxy)propyl]-; AC1O4XL1; CHEMBL19173; GTPL1255; SCHEMBL4072620; SCHEMBL15929504; BDBM22915; CHEBI:93359; WNWALBVQAAIULR-UHFFFAOYSA-N; 4-(3-Benzyloxypropyl)-1H-imidazole; ZINC13813304; 5-[3-(benzyloxy)propyl]-1H-imidazole; 5-(3-phenylmethoxypropyl)-1H-imidazole; NCGC00159580-01; 4-[3-(phenylmethoxy)propyl]-3H-imidazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H16N2O
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| Canonical SMILES |
C1=CC=C(C=C1)COCCCC2=CN=CN2
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| InChI |
1S/C13H16N2O/c1-2-5-12(6-3-1)10-16-8-4-7-13-9-14-11-15-13/h1-3,5-6,9,11H,4,7-8,10H2,(H,14,15)
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| InChIKey |
WNWALBVQAAIULR-UHFFFAOYSA-N
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| CAS Number |
CAS 177708-09-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:93359
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1255). | |||
| REF 2 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | |||
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