Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00KFI
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| Drug Name |
Azetidinyl-piperazine derivative 3
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| Synonyms |
PMID29053063-Compound-2b
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H18ClF3N4O2S2
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| Canonical SMILES |
C1CN(CCN1C2CN(C2)C(=O)C3=C(C4=C(S3)C=C(C=C4)C(F)(F)F)Cl)C(=O)C5=CSC=N5
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| InChI |
1S/C21H18ClF3N4O2S2/c22-17-14-2-1-12(21(23,24)25)7-16(14)33-18(17)20(31)29-8-13(9-29)27-3-5-28(6-4-27)19(30)15-10-32-11-26-15/h1-2,7,10-11,13H,3-6,8-9H2
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| InChIKey |
HKKPDZNDQBHUOD-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Monoglyceride lipase (MAGL) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Monoglyceride lipase (MAGL) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol degradation | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Metabolic pathways | ||||
| Retrograde endocannabinoid signaling | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | ||||
| WikiPathways | Lipid digestion, mobilization, and transport | |||
| Glycerophospholipid biosynthesis | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. | |||
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