Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00NCJ
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| Drug Name |
Heterocycle-containing compound 5
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| Synonyms |
PMID25828189-Compound-17
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| Drug Type |
Small molecular drug
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| Company |
PFIZER INC. ASPNES, Gary, Erik DIDIUK, Mary, Theresa FILIPSKI, Kevin, James GUZMAN-PEREZ, Angel PFEFFERKORN, Jeffrey, Allen STEVENS, Benjamin, Dawson TU, Meihua, Mik
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| Structure |
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Download2D MOL |
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| Formula |
C25H26F3N5O3
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| Canonical SMILES |
CC(C)CC(C1=CN=C(N=C1)C2=CC=C(C=C2)C(F)(F)F)NC3=NC=C(C=C3)C(=O)NCCC(=O)O
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| InChI |
1S/C25H26F3N5O3/c1-15(2)11-20(33-21-8-5-17(12-30-21)24(36)29-10-9-22(34)35)18-13-31-23(32-14-18)16-3-6-19(7-4-16)25(26,27)28/h3-8,12-15,20H,9-11H2,1-2H3,(H,29,36)(H,30,33)(H,34,35)/t20-/m0/s1
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| InChIKey |
DROAORWMIULFBS-FQEVSTJZSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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