Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00PEU
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| Former ID |
DIB020731
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| Drug Name |
pirenperone
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| Synonyms |
R-47465
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C23H24FN3O2
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| Canonical SMILES |
CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F
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| InChI |
1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
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| InChIKey |
HXCNRYXBZNHDNE-UHFFFAOYSA-N
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| CAS Number |
CAS 75444-65-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855539, 5518524, 8152980, 10321799, 11111590, 11111591, 11341934, 11362117, 11364478, 11367040, 11369602, 11372728, 11374319, 11377764, 11466559, 11467679, 11485635, 11486198, 11487519, 11489496, 11491470, 11492435, 11495398, 14756637, 17405565, 24278110, 26612664, 26680560, 26746907, 26746908, 29223928, 46386967, 47207164, 47291338, 47440496, 47810995, 47959985, 48110691, 48185200, 48259470, 49698543, 50065155, 50100304, 50103904, 50103905, 50122680, 50122681, 52893072, 53778113, 56422490
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| ChEBI ID |
CHEBI:92444
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 7 receptor (HTR7) | Target Info | Antagonist | [2] |
| KEGG Pathway | Ras signaling pathway | |||
| Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | |||
| Reactome | Serotonin receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 283). | |||
| REF 2 | Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32. | |||
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