Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00PIE
|
|||
| Former ID |
DIB004657
|
|||
| Drug Name |
Banoxantrone
|
|||
| Synonyms |
AQ4M; AQ4N; AZD-1689; AQ4N, AstraZeneca/Novacea
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Acute lymphoblastic leukaemia [ICD-11: 2A85; ICD-10: C85.1, C88.7] | Discontinued in Phase 1 | [1] | |
| Company |
KuDOS Pharmaceuticals; Novacea
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H28N4O6
|
|||
| Canonical SMILES |
C[N+](C)(CCNC1=C2C(=C(C=C1)NCC[N+](C)(C)[O-])C(=O)C3=C(C=CC(=C3C2=O)O)O)[O-]
|
|||
| InChI |
1S/C22H28N4O6/c1-25(2,31)11-9-23-13-5-6-14(24-10-12-26(3,4)32)18-17(13)21(29)19-15(27)7-8-16(28)20(19)22(18)30/h5-8,23-24,27-28H,9-12H2,1-4H3
|
|||
| InChIKey |
YZBAXVICWUUHGG-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 136470-65-0
|
|||
| PubChem Compound ID | ||||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Escherichia coli Nissle 1917
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Increase activity | |||
| Description | Banoxantrone can be metabolized by Escherichia coli Nissle 1917, which results in the increase of the drug's activity. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004590) | |||
| REF 2 | Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015 Sep 29;5:14554. | |||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.