Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00RDY
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| Former ID |
DNC000089
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| Drug Name |
5'-iodotubercidin
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| Synonyms |
5-Iodotubercidin; 24386-93-4; 5-iodotubericidin; 7-Deaza-7-iodoadenosine; 7-iodo-7-deazaadenosine; 7-iodotubercidin; (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL; CHEMBL99203; CHEBI:40167; 5-iodo-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NSC 113939; 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,5-iodo-7-b-D-ribofuranosyl-; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-iodo-7-beta-D-ribofuranosyl-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H13IN4O3
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| Canonical SMILES |
C1=CN(C2=NC=NC(=C21)N)C3C(C(C(O3)CI)O)O
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| InChI |
1S/C11H13IN4O3/c12-3-6-7(17)8(18)11(19-6)16-2-1-5-9(13)14-4-15-10(5)16/h1-2,4,6-8,11,17-18H,3H2,(H2,13,14,15)/t6-,7-,8-,11-/m1/s1
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| InChIKey |
RUOLUSLZJXGWAU-KCGFPETGSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID |
814098, 7979324, 8142631, 10228828, 15376461, 44427634, 46506259, 46530621, 50070345, 50070993, 53776847, 57336426, 57551400, 77287794, 85182436, 103059250, 103312988, 104121467, 104420528, 119525449, 121270651, 123121566, 134223996, 134964993, 135054302, 135697851, 135935198, 137014326, 152258715, 160643784, 160647550, 160854744, 160967600, 164043857, 165246158, 170481936, 175613967, 180096528, 186014773, 223384617, 223703164, 224057599, 226657244, 241043890, 241375590, 252156059, 252214541, 252418448, 252465658
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine kinase (ADK) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of purine nucleotide salvage | |||
| Adenine and adenosine salvage II | ||||
| KEGG Pathway | Purine metabolism | |||
| Metabolic pathways | ||||
| Reactome | Purine salvage | |||
| WikiPathways | Metabolism of nucleotides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism. Osteoarthritis Cartilage. 2005 Mar;13(3):250-7. | |||
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