Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00SVU
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| Former ID |
DNC001519
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| Drug Name |
Y-25130
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| Synonyms |
Azasetron; Nazasetron; Azasetron [INN]; C17H20ClN3O3; 123039-99-6; WUKZPHOXUVCQOR-UHFFFAOYSA-N; Azasetron (INN); 6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide; NCGC00024563-02; DSSTox_RID_81029; DSSTox_CID_25651; DSSTox_GSID_45651; (- )-6-Chloro-3,4-dihydro-4-methyl-3-oxo-N-3-quinuclidinyl-2H-1,4-benzoxazine-8-carboxamide; N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Nausea and vomiting [ICD-11: MD90; ICD-10: R11] | Approved | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H20ClN3O3
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| Canonical SMILES |
CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4
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| InChI |
1S/C17H20ClN3O3/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23)
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| InChIKey |
WUKZPHOXUVCQOR-UHFFFAOYSA-N
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| CAS Number |
CAS 123040-69-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4503337, 8151522, 14900802, 26751695, 29221437, 47437793, 48407470, 49830627, 50064274, 50064275, 51091806, 57321227, 77940238, 85787806, 103848318, 104300087, 117466756, 119525144, 124886910, 124886911, 126669656, 129635800, 135157445, 135649974, 136933682, 137249308, 137267099, 142183976, 144204457, 152103821, 160824111, 162180413, 163092086, 170466158, 179149724, 179565728, 184545075, 184557777, 204383376, 223656708, 226407307, 238185794, 249979213, 252358890
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| ChEBI ID |
CHEBI:91712
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Antagonist | [4] |
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2285). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000557) | |||
| REF 4 | The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur J Pharmacol. 1991 Apr 24;196(3):299-305. | |||
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