Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00UIN
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| Former ID |
DNC009560
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| Drug Name |
JNJ-10392980
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| Synonyms |
841200-46-2; benzoxazole,2-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-; JNJ-10392980; Benzoxazole compound, 10b; CHEMBL481863; SCHEMBL2170316; BDBM24203; ZIQGASWXUSSORV-UHFFFAOYSA-N; ZINC36377694; KB-306080; 2-[4-(2-Piperidin-1-yl-ethoxy)-phenoxy]-benzooxazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H22N2O3
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| Canonical SMILES |
C1CCN(CC1)CCOC2=CC=C(C=C2)OC3=NC4=CC=CC=C4O3
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| InChI |
1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2
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| InChIKey |
ZIQGASWXUSSORV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Inhibitor | [1] |
| Leukotriene A-4 hydrolase (LTA4H) | Target Info | Inhibitor | [1] | |
| Voltage-gated potassium channel Kv11.1 (KCNH2) | Target Info | Inhibitor | [1] | |
| BioCyc | Leukotriene biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Arachidonic Acid Metabolism | ||||
| Reactome | Voltage gated Potassium channels | |||
| Serotonin receptors | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Potassium Channels | ||||
| Arachidonic acid metabolism | ||||
| Eicosanoid Synthesis | ||||
| Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. | |||
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