Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00XWB
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| Former ID |
DIB001382
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| Drug Name |
F-15845
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| Synonyms |
UNII-3VKL9K971D; 3VKL9K971D; F-15845; (-)-F-15845; 2H-1,5-Benzoxathiepin-3-amine, 3,4-dihydro-N-((2S)-3-((2-methoxyphenyl)thio)-2-methylpropyl)-, hydrobromide, (3R)-; 3-(R)-(3-(2-Methoxyphenylthio-2-(S)-methylpropyl)amino)-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate; (-)-(3R)-N-((2S)-3-((2-Methoxyphenyl)sulfanyl)-2-methylpropyl)-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine hydrobromide
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Phase 1 | [1] | |
| Company |
Pierre Fabre SA
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| Structure |
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Download2D MOL |
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| Formula |
C20H26BrNO2S2
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| Canonical SMILES |
CC(CNC1COC2=CC=CC=C2SC1)CSC3=CC=CC=C3OC.Br
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| InChI |
1S/C20H25NO2S2.BrH/c1-15(13-24-19-9-5-3-7-17(19)22-2)11-21-16-12-23-18-8-4-6-10-20(18)25-14-16;/h3-10,15-16,21H,11-14H2,1-2H3;1H/t15-,16+;/m0./s1
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| InChIKey |
CUWFVJMNULNBTG-IDVLALEDSA-N
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| CAS Number |
CAS 866760-23-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.5 (SCN5A) | Target Info | Inhibitor | [2], [3] |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | |||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Interaction between L1 and Ankyrins | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Cardiac Progenitor Differentiation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023448) | |||
| REF 2 | Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91. | |||
| REF 3 | A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation. Pharmacogenomics J. 2014 Aug;14(4):372-5. | |||
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